paris 12 ue1 biochimie fiche de cours n°13 seances medisup (pr. loric) chaine respiratoire mitochondriale “*les notions indiquées tombent fréquemment au. Les mitochondries sont preparees par centrifugation diffe- rentielle dans un milieu structure de l’antibiotique-activite sur la chaine respiratoire mitochondriale. Le dinitrophénol (DNP) est un composé chimique aromatique de formule C6H4N 2O5. C’est un Le dinitrophénol est un découplant de la chaîne respiratoire mitochondriale. Les intoxications aux dérivés nitrés du phénol sont reconnues.

Author: Teran Akinorn
Country: Mongolia
Language: English (Spanish)
Genre: Relationship
Published (Last): 10 November 2007
Pages: 335
PDF File Size: 15.71 Mb
ePub File Size: 15.55 Mb
ISBN: 879-5-87384-876-2
Downloads: 64812
Price: Free* [*Free Regsitration Required]
Uploader: Nacage

Médecine thérapeutique

In mammals, rexpiratoire two types of adipose tissues are described: Whereas WAT represents the main energy storage in the organism, BAT dissipates energy as heat through the expression of the uncoupling protein UCP1 uncoupling protein-1 that uncouples the functioning of the respiratory chain from ATP synthase.

While both white and rsepiratoire adipocytes have been considered for a long time as two very close cellular types sharing a common precursor, recent data challenge these conclusions and propose the existence of a new possible type of adipocyte, the BRITE brown-in-white adipocyte. In parallel, the recent discovery of significant amounts of BAT in human adults mitochondruale renewed the interest of miitochondriale scientific community for this tissue.

Given its considerable capacity to dissipate substrates, BAT appears again as a therapeutic target against metabolic diseases such as diabetes and obesity. PR domain containing 16 ; DIO2: Data correspond to usage on the plateform after The current usage metrics is available hours after online publication and is updated daily on week days.


Issue Med Sci Paris. Med Sci Paris ; Brown adipose tissue thermogenesis: Thermogenic mechanisms in brown fat.

Physiol Rev ; Uncoupling protein 1 of brown adipocytes, the only uncoupler: Front Endocrinol Lausanne ; 2: Developmental origins of the adipocyte lineage: Stem Cell Rev ; 8: Nature ; Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

Occurrence of brown adipocytes in rat white adipose tissue: J Cell Sci ; Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell ; Nitochondriale vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab ; In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat mitochonxriale.

Animation flash

Obes Rev ; Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Sudden hcaine of uncoupling protein mRNA during embryogenesis and its disappearance after birth. Biochem J ; Pharmacological and nutritional agents promoting browning of white adipose tissue. Biochim Biophys Acta ; A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.

Detection of brown adipose tissue uncoupling mitoxhondriale mRNA in adult patients by a human genomic probe.

Clin Sci Lond ; Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab ; Brown adipose tissue oxidative metabolism contributes respiratoore energy expenditure during acute cold exposure in humans. J Clin Invest ; Cold-activated brown adipose tissue in healthy men. N Engl J Med ; A reservoir of brown adipocyte progenitors in human skeletal muscle.


Stem Cells ; Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle. Int J Obes Lond ; Front Endocrinol Lausanne ; 3: Brown adipose tissue activity controls triglyceride clearance.

NADH déshydrogénase — Wikipédia

Nat Med ; Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

Development of obesity in transgenic mice after genetic ablation of mitocjondriale adipose tissue.

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab ; 9: Reversal of type 1 diabetes in mice by brown adipose tissue transplant.

Diabetes ; Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. Fibroblast growth factor Diabetes Metab J ; Ectopic brown adipose tissue in rrespiratoire provides a mechanism for differences in risk of metabolic syndrome in mice.


PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Current usage metrics About article metrics Return to article.

Initial download of the metrics may take a while. Previous article Next article. Metrics Show article metrics. Services Articles citing this article CrossRef 6.