paris 12 ue1 biochimie fiche de cours n°13 seances medisup (pr. loric) chaine respiratoire mitochondriale “*les notions indiquées tombent fréquemment au. Les mitochondries sont preparees par centrifugation diffe- rentielle dans un milieu structure de l’antibiotique-activite sur la chaine respiratoire mitochondriale. Le dinitrophénol (DNP) est un composé chimique aromatique de formule C6H4N 2O5. C’est un Le dinitrophénol est un découplant de la chaîne respiratoire mitochondriale. Les intoxications aux dérivés nitrés du phénol sont reconnues.
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In mammals, rexpiratoire two types of adipose tissues are described: Whereas WAT represents the main energy storage in the organism, BAT dissipates energy as heat through the expression of the uncoupling protein UCP1 uncoupling protein-1 that uncouples the functioning of the respiratory chain from ATP synthase.
While both white and rsepiratoire adipocytes have been considered for a long time as two very close cellular types sharing a common precursor, recent data challenge these conclusions and propose the existence of a new possible type of adipocyte, the BRITE brown-in-white adipocyte. In parallel, the recent discovery of significant amounts of BAT in human adults mitochondruale renewed the interest of miitochondriale scientific community for this tissue.
Given its considerable capacity to dissipate substrates, BAT appears again as a therapeutic target against metabolic diseases such as diabetes and obesity. PR domain containing 16 ; DIO2: Data correspond to usage on the plateform after The current usage metrics is available hours after online publication and is updated daily on week days.
Issue Med Sci Paris. Med Sci Paris ; Brown adipose tissue thermogenesis: Thermogenic mechanisms in brown fat.
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Development of obesity in transgenic mice after genetic ablation of mitocjondriale adipose tissue.
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab ; 9: Reversal of type 1 diabetes in mice by brown adipose tissue transplant.
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PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Current usage metrics About article metrics Return to article.
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